The septum is the wall of bone and cartilage that divides the nose into two separate nostrils. Nasal Septum Perforation Surgery is for defects of the nasal septum. Nasal Septum Perforation aims to straighten your deviated nasal septum. During Nasal Septum Perforation Treatment, the doctor may take a tissue graft from the inside of the nose or from another part of the body to fill in the septal hole. You must avoid any nose-picking and recreational drugs after surgery.